OBAGI Medical Tretinoin Cream 0.1%

A prescription-strength retinoid trusted by dermatologists for decades. Obagi Tretinoin Cream is a topical treatment powered by tretinoin — a form of retinoic acid derived from Vitamin A and widely recognized as one of the most effective, well-studied acne treatments available. Working deep within the skin, it targets acne at its source to help clear breakouts and support a smoother, healthier-looking complexion.

Backed by Obagi's 30-year legacy of science and innovation, this fragrance-free formula is available in multiple strengths so your provider can tailor treatment to your skin's needs and tolerance.

Available strengths: Obagi Tretinoin comes in 0.025%, 0.05%, and 0.1% cream, as well as a 0.05% gel. Your provider will recommend the right strength and formulation for you — higher concentrations are typically reserved for those who have already built tolerance to tretinoin.

How to use (general guidance): Tretinoin is typically applied at night. Wash with a mild cleanser and let skin dry completely (about 20–30 minutes). Apply a thin layer — no more than about a half-inch — lightly over the affected area, avoiding the corners of the nose, mouth, eyes, and any open skin. Because tretinoin increases sun sensitivity, daily sunscreen and sun protection are essential. Always follow your provider's specific instructions.

Important — prescription required: Obagi Tretinoin is a prescription drug indicated for the topical treatment of acne vulgaris and must be prescribed and supervised by a qualified healthcare provider. [Schedule a consultation to find out if tretinoin is right for your skin.]